p53 protein expression and its prognostic importance in patients with nodal non-Hodgkin's lymphoma.

نویسندگان

  • M. J. Ahn
  • H. Kim
  • I. S. Kim
  • J. K. Park
  • M. R. Ki
  • C. K. Park
چکیده

To determine whether the p53 expression might be a predictor for treatment response and overall survival in nodal non-Hodgkin's lymphoma (NHL), we analyzed the expression of p53 in 69 NHL patients. p53 protein expression was analyzed by immunohistochemistry with long-term follow up (1-148 months: median 12.2). p53 expression was noted in 23/69 (33.3%) patients. Complete response (CR) rate to systemic chemotherapy was correlated with stage (I/II) (p=0.038), but not with p53 expression (p=0.2856). Poor overall survival was associated with stage (p=0.0010) or IPI score (p=0.0076), but not with p53 expression (p=0.8601). From stratification analysis by stage, in stage III/IV patients, the p53 positive group had a trend to be associated with poor overall survival than the p53 negative group. Multivariate analysis revealed that p53 positive group was associated with less CR rate compared to the p53 negative group (p=0.046), whereas overall survival was correlated with stage (p=0.0320), not with p53 status. p53 expression was associated with less CR rate in patients with DLBL. Further studies with large numbers of samples and homogenous group of NHL are needed to determine the prognostic value of cell cycle regulator, p53 in NHL.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

p53 Protein Expression and Its Relation to the Apoptotic Index in Prostate Adenocarcinoma

Background: Prostate cancer is one of the most commonly diagnosed cancers in males. Tumor suppressor gene p53 plays an important role in causing cell cycle arrest and allowing apoptosis to proceed. Objective: To investigate the expression of p53 protein and its relation to apoptosis and prostate cancer traditional prognostic indicators. Methods: In this study expression of p53 was examined in p...

متن کامل

Evaluation of prognostic factors affecting long and short term survival rates of Hodgkin's lymphoma patients using the cure fraction models

Background and Aim: This study aimed to analyze the factors affecting time and experience of relapse in the patients with Hodgkin's lymphoma, using cure fraction. Material and Methods: This retrospective study included all the patients diagnosed as Hodgkin's lymphoma in the Center for oncology and hematology in Shafa Hospital in Ahwaz City from 2002 to 2012. We used survival analysis and cure f...

متن کامل

بررسی بیان مارکرهای سیکلو اکسیژنازII و p-53 و ارتباط آن ها با بقاء 5 ساله در بیماران مبتلا به لنفوم هوچکین

Introduction & Objective: Hodgkin lymphoma accounts for about 1% of all cancers. Cyclooxygenase 2 (COX2) is a cytoplasmic enzyme. Oncogene, and growth factor induce over expression of COX2. COX2 is apoptotic inhibitor. Mutation of the p53 tumor suppressor gene represents the most common genetic alternation in human tumors. This study aimed to evaluate the expression of COX2 and p53 in subtype...

متن کامل

Expression of cyclin B1 and cdc2 in nodal non-Hodgkin's lymphoma and its prognostic implications.

To investigate the role of cyclin B1 and cdc2 in the pathogenesis and progression of malignant lymphoma, 68 cases of nodal non-Hodgkin's lymphoma were examined about the expression of cyclin B1 and cdc2 along with p53 and Ki-67 by immunohistochemical method. The correlation of their expression with various clinicopathologic findings was also analyzed. Cyclin B1 and cdc2 were diffusely expressed...

متن کامل

Prognostic value of p53 in renal cell carcinoma

Background and Objectives: RCC is one of the most common genitourinary cancers. Accurate prediction of prognosis would be valuable for adjuvant trial design, counseling and effectively scheduling follow up visits. P53 is a tumor suppressor gene that expresses a protein that involved in both cell-cycle ar...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Journal of Korean Medical Science

دوره 15  شماره 

صفحات  -

تاریخ انتشار 2000